Saint-Andre named a 31-man squad and once again Trinh-Duc finds himself out in the cold, with Michalak recalled as back up for first-choice flyhalf Remi Tales.
Although first choice under Saint-Andre’s predecessor Marc Lievremont, Trinh-Duc has found himself eased out of international reckoning under the new coach.
The 26-year-old, who has played 49 times for France, has been in scintillating form for his club recently, but Saint-Andre insists his omission is not personal.
“There is no case surrounding Trinh-Duc. He was on the tour to Argentina [in 2012], he played in the Six Nations when there were injuries,” said the coach.
“We make choices. Tales is our first choice, Michalak is coming back as a flyhalf [having often been played at scrumhalf by Toulon].
“I make decisions and I take responsibility for them.
“Francois is in good form but we also have to talk about Jules Plisson and Camille Lopez, who will join Clermont.
“Everyone is working hard, just like Francois Trinh-Duc.
“Based on the balance of the squad and the team we’re building, Remi Tales remains our first choice.”
Since the end of the 2013 Six Nations tournament, where he was mostly second choice to Michalak at No.10, Trinh-Duc has made just one 13-minute appearance for France as substitute.
Even when Tales was out injured during the 2014 Six Nations, Trinh-Duc was overlooked for a starting berth in favour of young Stade Francais flyhalf Plisson.
The omission is all the more surprising as Michalak had been completely overlooked throughout the Six Nations in February and March, only to now be welcomed back into the fold.
His cause, however, has been helped by deputising for Jonny Wilkinson at flyhalf far more this season than the last, when he was mostly used as a No.9.
Three players are set to make their debuts for France if they play in Australia with uncapped trio, Toulon prop Alexandre Menini, Castres centre Remi Lamerat and Bordeaux-Begles wing Felix Le Bourhis the surprise inclusions in the squad.
France play Australia in Brisbane on June 7, in Melbourne a week later and then round off their three-match tour in Sydney on June 21.
Forwards: Thomas Domingo (Clermont), Alexandre Menini (Toulon), Guilhem Guirado (Perpignan), Benjamin Kayser (Clermont), Christopher Tolofua (Toulouse), Vincent Debaty (Clermont), Nicolas Mas (Montpellier), Rabah Slimani (Stade Francais), Alexandre Flanquart (Stade Francais), Bernard Le Roux (Racing-Metro), Yoann Maestri (Toulouse), Sebastien Vahaamahina (Perpignan), Antoine Burban (Stade Francais), Damien Chouly (Clermont), Thierry Dusautoir (Toulouse, capt.), Yannick Nyanga (Toulouse), Fulgence Ouedraogo (Montpellier), Louis Picamoles (Toulouse).
Backs: Maxime Machenaud (Racing-Metro), Morgan Parra (Clermont), Frederic Michalak (Toulon), Remi Tales (Castres), Mathieu Bastareaud (Toulon), Gael Fickou (Toulouse), Wesley Fofana (Clermont), Remi Lamerat (Castres), Yoann Huget (Toulouse), Felix Le Bourhis (Bordeaux-Begles), Maxime Medard (Toulouse), Hugo Bonneval (Stade Francais), Brice Dulin (Castres).