Springbok centre Juan de Jongh has been restored to the starting line-up, following his return from injury via the bench last weekend.
The return of De Jongh means a switch back to inside centre for captain Jean de Villiers and Damian de Allende moving back to the wing where he began the 2014 season.
Louis Schreuder will come in at scrumhalf, with Nic Groom dropping down to the bench after three starts in a row.
In a final backline change, Kobus van Wyk drops out of the matchday 23 altogether this week, with Jaco Taute back on the bench after resting his troublesome AC Joint against the Brumbies.
Western Province Under-21 star Jurie van Vuuren will make his first Super Rugby start, after being named to partner Michael Rhodes at lock.
Van Vuuren, who came off the bench last week, is a product of the WP Rugby Institute in Stellenbosch and has lifted silverware with the WP Under-19 (2012) and Under-21 (2013) teams in the past two seasons.
His promotion to the starting XV, in the absence of injured lock Ruan Botha, is one of three changes to the Stormers pack that started against the Brumbies in Canberra last Saturday – the others see Deon Fourie start at hooker and Nizaam Carr come in at No.6.
Taute, in turn, will be joined on the bench by WP Vodacom Cup stars, lock Mthetheleli Fuzani and loose forward Sikhumbuzo Notshe.
Both Fuzani and Notshe, who arrived in Brisbane just a day ago, are uncapped at Super Rugby level.
Fuzani, 23, played three Currie Cup matches for Western Province last season, to go with nine appearances at Vodacom Cup level, whilst Notshe – who left school at the end of 2012 – has played 12 Vodacom Cup matches for Province.
“We’d dearly love to finish our tour with a victory in Brisbane,” Coetzee said.
“We know it won’t be easy, but the guys remain positive and determined to make it count this weekend against a Reds team that will also be desperate to get back to winning ways after two losses in South Africa.”
Stormers: 15 Gio Aplon, 14 Damian de Allende, 13 Juan de Jongh, 12 Jean de Villiers (captain), 11 Sailosi Tagicakibau, 10 Peter Grant, 9 Louis Schreuder, 8 Duane Vermeulen, 7 Siya Kolisi, 6 Nizaam Carr, 5 Michael Rhodes, 4 Jurie van Vuuren, 3 Frans Malherbe, 2 Deon Fourie, 1 Steven Kitshoff.
Replacements: 16 Stephan Coetzee, 17 Oliver Kebble, 18 Brok Harris, 19 Tazz Fuzani, 20 Sikhumbuzo Notshe, 21 Nic Groom, 22 Demetri Catrakilis, 23 Jaco Taute.