The Leicester Tigers front-rower will have a period of rest from rugby to relieve a bulging disc in his neck which is trapping a nerve.
The 26-year-old Cole has become something of a mainstay since making his debut off the bench against Wales in 2010.
The Leicester Tigers and England tight-head prop was diagnosed after experiencing weakness during a gym session at St George’s Park last week.
Cole will have further specialist assessment on Tuesday evening and England Head Coach Stuart Lancaster said, “It’s massively disappointing for Dan, Leicester and England but the important thing is that this has been diagnosed and that Dan gets the appropriate rest and treatment.
“Our medics are working closely with Leicester’s to come up with a programme that will ensure Dan returns in the best possible shape. In the meantime, it’s great to have David Wilson back, as well as Henry Thomas who has trained well and came off the bench against Scotland and this will be an opportunity to develop experience in this area.”
Leicester Tigers Director of Rugby Richard Cockerill said,”It’s very disappointing for us and for England, and obviously for Dan, but his long-term fitness is more important. He’ll have time to get over this issue and come back when the medical teams are satisfied with his progress.
The following players reported to Pennyhill Park this evening to prepare for Saturday’s 6 Nations match against Ireland at Twickenham.
Forwards (17) David Attwood (Bath Rugby) Dylan Hartley (Northampton Saints) Matt Kvesic (Gloucester Rugby) Tom Johnson (Exeter Chiefs) Joe Launchbury (London Wasps) Courtney Lawes (Northampton Saints) Joe Marler (Harlequins) Ben Morgan (Gloucester Rugby) Matt Mullan (London Wasps) Chris Robshaw (Harlequins) Ed Slater (Leicester Tigers) Henry Thomas (Sale Sharks) Billy Vunipola (Saracens) Mako Vunipola (Saracens) David Wilson (Bath Rugby) Tom Wood (Northampton Saints) Tom Youngs (Leicester Tigers)
Backs (16) Chris Ashton (Saracens) Brad Barritt (Saracens) Mike Brown (Harlequins) Freddie Burns (Gloucester Rugby) Luther Burrell (Northampton Saints) Danny Care (Harlequins) Lee Dickson (Northampton Saints) Kyle Eastmond (Bath Rugby) Owen Farrell (Saracens) George Ford (Bath Rugby) Alex Goode (Saracens) Jonny May (Gloucester Rugby) Jack Nowell (Exeter Chiefs) Billy Twelvetrees (Gloucester Rugby) Anthony Watson (Bath Rugby) Ben Youngs (Leicester Tigers)